HDAC8-IN-1

HDAC8-IN-1 is an inhibitor of histone deacetylase 8 (HDAC8, IC50 = 27.2 nM). It is selective for HDAC8 over HDAC1-3, -4, -6, -10, and -11 (IC50s = >3,000 nM for all). HDAC8-IN-1 is cytotoxic to A549, H1299, and CL1-5 lung cancer cells (IC50s = 7.9, 7.2, and 7 µM, respectively).Formal Name: (2E)-N-hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-2-propenamide. CAS Number: 1417997-93-3. Synonyms: MDK-7933. Molecular Formula: C22H19NO3. Formula Weight: 345.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: COC1=CC=C(/C=C/C(NO)=O)C(C2=CC=C(C3=CC=CC=C3)C=C2)=C1. InChi Code: InChI=1S/C22H19NO3/c1-26-20-13-11-19(12-14-22(24)23-25)21(15-20)18-9-7-17(8-10-18)16-5-3-2-4-6-16/h2-15,25H,1H3,(H,23,24)/b14-12+. InChi Key: ASHPRZYGCOMVHO-WYMLVPIESA-N.