HDAC3 Inhibitor

HDAC3 inhibitor is an allosteric inhibitor of histone deacetylase 3 (HDAC3, Ki = 0.16 nM). It is selective for HDAC3 over HDAC1 and HDAC2 (IC50s = 0.95, 11.81, and 95.45 nM, respectively, using recombinant HDACs). In addition, it is selective for acute myeloid, monocytic, and lymphoblastic leukemia cell lines (EC50s = 36.37, 76.64, and 151.7 nM, respectively) over chronic myeloid, acute promyelocytic, and acute lymphoblastic cells (EC50s = 2,160, >10,000, and >10,000 nM, respectively).Formal Name: 4-[[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]amino]methyl]-benzoic acid 2-propylhydrazide. CAS Number: 2044701-99-5. Synonyms: Histone Deacetylase 3. Molecular Formula: C20H23N3O2. Formula Weight: 337.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: Soluble, DMSO: Soluble, Ethanol: Soluble. lambdamax: 217, 223, 274 nm. SMILES: O=C(NCC1=CC=C(C(NNCCC)=O)C=C1)/C=C/C2=CC=CC=C2. InChi Code: InChI=1S/C20H23N3O2/c1-2-14-22-23-20(25)18-11-8-17(9-12-18)15-21-19(24)13-10-16-6-4-3-5-7-16/h3-13,22H,2,14-15H2,1H3,(H,21,24)(H,23,25)/b13-10+. InChi Key: MHZUZIALEUTHIU-JLHYYAGUSA-N.