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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay26116-500 | 500 µg | - |
6 - 10 business days* |
163.00€
|
|||
Cay26116-1 | 1 mg | - |
6 - 10 business days* |
308.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Haloperidol-d4 is intended for use as an internal standard for the quantification of haloperidol... more
Product information "Haloperidol-d4"
Haloperidol-d4 is intended for use as an internal standard for the quantification of haloperidol (Cay-12014) by GC- or LC-MS. Haloperidol is a typical antipsychotic and dopamine D2-like receptor antagonist (Kis = 0.6, 0.2, and 22 nM, for D2, D3, and D4 receptors, respectively). It also acts as an inverse agonist at dopamine D2 and D3 receptors (IC50s = 0.8 and 0.6 nM, respectively). Haloperidol also binds to alpha1- and alpha2- adrenergic and histamine H1 receptors, as well as the serotonin (5-HT) receptor subtypes 5-HT1D and 5-HT2A (Kds = 17, 600, 260, 40, and 61 nM, respectively). It inhibits stereotypic behavior induced by apomorphine (Cay-16094) and amphetamine in rats (ID50s = 0.532 and 0.101 µmol/kg, respectively). Haloperidol also inhibits apomorphine-induced decreases in prepulse inhibition of the acoustic startle response in rats in a dose-dependent manner. Formulations containing haloperidol have been used in the treatment of schizophrenia and Tourette syndrome.Formal Name: 4-(4-(4-chlorophenyl-2,3,5,6-d4)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one. CAS Number: 1189986-59-1. Molecular Formula: C21H19ClD4FNO2. Formula Weight: 379.9. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly Soluble, Methanol: Slightly Soluble. SMILES: OC1(CCN(CCCC(C2=CC=C(F)C=C2)=O)CC1)C3=C([2H])C([2H])=C(Cl)C([2H])=C3[2H]. InChi Code: InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2/i5D,6D,7D,8D. InChi Key: LNEPOXFFQSENCJ-KDWZCNHSSA-N.
Keywords: | 4-(4-(4-chlorophenyl-2,3,5,6-d4)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one |
Supplier: | Cayman Chemical |
Supplier-Nr: | 26116 |
Properties
Application: | Dopamine D2 receptor antagonist, GC-MS, LC-MS, Internal standard |
MW: | 379.9 D |
Formula: | C21H19ClD4FNO2 |
Purity: | >99% deuterated forms (d1-d4) |
Format: | Solid |
Database Information
CAS : | 1189986-59-1| Matching products |
KEGG ID : | K04145 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
|
H Phrases: | H301, H315, H317, H319, H335, H361 |
P Phrases: | P201, P202, P261, P264, P270, P271, P272, P280, P301+310, P302+352, P304+340, P305+351+338, P308+313, P312, P321, P330, P332+313, P333+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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