Halofantrine (hydrochloride)

Halofantrine is an antimalarial agent. It is active against chloroquine-sensitive and chloroquine-resistant strains of P. falciparum (IC50s = 1.5-2.5 and 1.3-3.9 µg/L, respectively). Halofantrine reduces parasitemia in a mouse model of P. berghei infection with a 50% curative dose (CD50) value of 15 mg/kg. It also reduces parasitemia in an Aotus monkey model of P. falciparum infection (CD50 = 58.3 mg/kg). Formulations containing halofantrine have been used in the treatment of malaria.Formal Name: 1,3-dichloro-alpha-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-9-phenanthrenemethanol, monohydrochloride. CAS Number: 36167-63-2. Synonyms: (±)-Halofantrine, SKF 102886, WR 171669. Molecular Formula: C26H30Cl2F3NO . HCl. Formula Weight: 536.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble, Methanol: soluble. lambdamax: 216, 232, 259 nm. SMILES: FC(F)(F)C1=CC2=C3C(C(Cl)=CC(Cl)=C3)=CC(C(O)CCN(CCCC)CCCC)=C2C=C1.Cl. InChi Code: InChI=1S/C26H30Cl2F3NO.ClH/c1-3-5-10-32(11-6-4-2)12-9-25(33)23-16-22-21(14-18(27)15-24(22)28)20-13-17(26(29,30)31)7-8-19(20)23,/h7-8,13-16,25,33H,3-6,9-12H2,1-2H3,1H. InChi Key: WANGFTDWOFGECH-UHFFFAOYSA-N.