H-151

H-151 is an inhibitor of stimulator of interferon genes (STING). It forms an adduct with mouse STING in serum and acts in an irreversible manner. It inhibits the type I interferon (IFN) response and reduces the phosphorylation of TBK1 and palmitoylation of human STING (hsSTING) in vitro. It also reduces increases in mouse serum levels of IFN-beta and IL-6 induced by the STING agonist 10-carboxymethyl-9-acridanone (CMA).Formal Name: N-(4-ethylphenyl)-N'-1H-indol-3-yl-urea. CAS Number: 941987-60-6. Molecular Formula: C17H17N3O. Formula Weight: 279.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMSO: 30 mg/mL, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/mL, Ethanol: 10 mg/mL. lambdamax: 236, 258 nm. SMILES: CCC1=CC=C(NC(NC2=CNC3=C2C=CC=C3)=O)C=C1. InChi Code: InChI=1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21). InChi Key: UJZDIKVQFMCLBE-UHFFFAOYSA-N.