GZD-824

GZD-824 is an orally available inhibitor of a broad spectrum of Bcr/Abl tyrosine kinase mutants including T315I (IC50s = 0.34 and 0.68 nM for wild-type Bcr/Abl and Bcr/AblT315I, respectively). It has been shown to suppress the proliferation of Bcr/Abl-positive K562 and Ku812 human chronic myelogenous leukemia cells (IC50s = 0.2 and 0.13 nM, respectively) and induce tumor regression in mouse xenograft tumor models driven by either wild-type or mutant Bcr/Abl.Formal Name: 4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]-benzamide. CAS Number: 1257628-77-5. Molecular Formula: C29H27F3N6O. Formula Weight: 532.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO:. lambdamax: 274, 324 nm. SMILES: CN1CCN(CC2=CC=C(NC(C3=CC(C#CC4=CN=C(NN=C5)C5=C4)=C(C)C=C3)=O)C=C2C(F)(F)F)CC1. InChi Code: InChI=1S/C29H27F3N6O/c1-19-3-5-22(14-21(19)6-4-20-13-24-17-34-36-27(24)33-16-20)28(39)35-25-8-7-23(26(15-25)29(30,31)32)18-38-11-9-37(2)10-12-38/h3,5,7-8,13-17H,9-12,18H2,1-2H3,(H,35,39)(H,33,34,36). InChi Key: TZKBVRDEOITLRB-UHFFFAOYSA-N.