GW848687X

Description: GW848687X, a potent and selective prostaglandin EP1 receptor antagonist, is used for the treatment of inflammatory pain. Target: Others. Smiles: O(CC1=C(F)C=C(F)C=C1)C2=C(C3=C(CCC3)C=4N=C(C(O)=O)C=CC4)C=C(Cl)C=C2. References: Giblin GM, Bit RA, Brown SH, Chaignot HM, Chowdhury A, Chessell IP, Clayton NM, Coleman T, Hall A, Hammond B, Hurst DN, Michel AD, Naylor A, Novelli R, Scoccitti T, Spalding D, Tang SP, Wilson AW, Wilson R. The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-p yridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain. Bioorg Med Chem Lett. 2007 Jan 15,17(2):385-9. PubMed PMID: 17084082.