Guvacine (hydrochloride)

Guvacine is an amino acid found in A. catechu (Betel nut). It competitively inhibits GABA uptake (IC50 = 10 µM, Ki = 14 µM) in rat hippocampal brain slices. In vivo, guvacine, at doses ranging from 50-100 mg/kg, decreases spontaneous activity in mice. Administration of guvacine also decreases tail flick reaction time in a rat model of morphine analgesia.Formal Name: 1,2,5,6-tetrahydro-3-pyridinecarboxylic acid, monohydrochloride. CAS Number: 6027-91-4. Molecular Formula: C6H9NO2 . HCl. Formula Weight: 163.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.25 mg/ml, DMSO: 20 mg/ml, Ethanol: 0.5 mg/ml, PBS (pH 7.2): 3 mg/ml. SMILES: OC(C1=CCCNC1)=O.Cl. InChi Code: InChI=1S/C6H9NO2.ClH/c8-6(9)5-2-1-3-7-4-5,/h2,7H,1,3-4H2,(H,8,9),1H. InChi Key: FGNUNVVTHHKDAM-UHFFFAOYSA-N.