GTPgammaS tetralithium

Description: GTPgammaS tetralithium (Guanosine 5'-[gamma-thio]triphosphate tetralithium) is a G-protein activator, a non-hydrolyzable GTP analog that protects proteins from proteolytic degradation.GTPgammaS tetralithium is involved in the detection of cells expressing recombinant receptors and endogenous receptors. GTPgammaS tetralithium is involved in the detection of GPCR signaling in cells expressing recombinant receptors as well as in cells and tissues expressing endogenous receptors, and can be assayed to measure agonist-induced desensitization of two human polymorphic alpha2B-adrenoceptor variants. Target: Others. Smiles: O[C@H]1[C@@H](O[C@@H]([C@H]1O)COP(OP(OP([O-])([S-])=O)([O-])=O)([O-])=O)N2C3=C(C(N=C(N3)N)=O)N=C2.[Li+].[Li+].[Li+].[Li+]. References: Hensler JG. Differential regulation of 5-HT1A receptor-G protein interactions in brain following chronic antidepressant administration. Neuropsychopharmacology. 2002 May,26(5):565-73.