GSK872

GSK872 is an inhibitor of receptor-interacting protein kinase 3 (RIPK3). It is selective for RIPK3, having >1,000-fold selectivity over 300 kinases in a fluorescence polarization assay at a concentration of 1 µM. GSK872 inhibits TNF- and virus-induced necrosis in 3T3-SA fibroblasts. It also inhibits necrosis induced by toll-like receptor 3 (TLR3).Formal Name: N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine. CAS Number: 1346546-69-7. Molecular Formula: C19H17N3O2S2. Formula Weight: 383.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:6): 0.15 mg/ml, Ethanol: 15 mg/ml. lambdamax: 224, 252, 362 nm. SMILES: CC(C)S(C1=CC(C(NC2=CC=C(SC=N3)C3=C2)=CC=N4)=C4C=C1)(=O)=O. InChi Code: InChI=1S/C19H17N3O2S2/c1-12(2)26(23,24)14-4-5-16-15(10-14)17(7-8-20-16)22-13-3-6-19-18(9-13)21-11-25-19/h3-12H,1-2H3,(H,20,22). InChi Key: ZCDBTQNFAPKACC-UHFFFAOYSA-N.