GSK3179106

GSK3179106 is an inhibitor of rearranged during transfection (RET) kinase (IC50 = 0.4 nM). It is selective for RET kinase over VEGF receptor 2 (VEGFR2/KDR, IC50 = 109 nM). GSK3179106 reduces the number of abdominal contractions induced by colorectal distension in acetic acid-sensitized rats when administered at a dose of 10 mg/kg twice per day.Formal Name: 4-(4-ethoxy-1,6-dihydro-6-oxo-3-pyridinyl)-2-fluoro-N-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]-benzeneacetamide. CAS Number: 1627856-64-7. Synonyms: RET Kinase Inhibitor 1. Molecular Formula: C22H21F4N3O4. Formula Weight: 467.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50mg/mL, DMSO: 50mg/mL, DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL, Ethanol: 25mg/mL. lambdamax: 209, 233 nm. SMILES: O=C1C=C(OCC)C(C2=CC(F)=C(CC(NC3=NOC(C(C)(C)C(F)(F)F)=C3)=O)C=C2)=CN1. InChi Code: InChI=1S/C22H21F4N3O4/c1-4-32-16-9-19(30)27-11-14(16)12-5-6-13(15(23)7-12)8-20(31)28-18-10-17(33-29-18)21(2,3)22(24,25)26/h5-7,9-11H,4,8H2,1-3H3,(H,27,30)(H,28,29,31). InChi Key: IDXKJSSOUXWLDB-UHFFFAOYSA-N.