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You can also order by e-mail: info@biomol.com
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1, IC50s = 16... more
Product information "GSK2982772"
GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1, IC50s = 16 and 2,500 nM for the human and mouse enzymes, respectively). It is greater than 10,000-fold selective for RIPK1 over a panel of 339 kinases at 10 µM. GSK2982772 inhibits necrotic cell death induced by a combination of TNF-alpha and the caspase inhibitor QVD-OPh in U937 human monocytic and L929 murine fibrosarcoma cells (IC50s = 6.3 and 1,300 nM, respectively). GSK2982772 (3-300 nM) decreases IL-1beta and IL-6 levels in intestinal mucosa tissue isolated from patients with ulcerative colitis. It increases survival in a mouse model of TNF-alpha-induced lethal shock when administered at doses of 3, 10, and 50 mg/kg.Formal Name: 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxo-1,5-benzoxazepin-3-yl]-1H-1,2,4-triazole-5-carboxamide. CAS Number: 1622848-92-3. Molecular Formula: C20H19N5O3. Formula Weight: 377.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10mg/mL, DMSO: 15mg/mL, DMSO:PBS (pH 7.2) (1:5): 0.16mg/mL, Ethanol: 5mg/mL. SMILES: CN1C2=CC=CC=C2OC[C@H](NC(C3=NN=C(CC4=CC=CC=C4)N3)=O)C1=O. InChi Code: InChI=1S/C20H19N5O3/c1-25-15-9-5-6-10-16(15)28-12-14(20(25)27)21-19(26)18-22-17(23-24-18)11-13-7-3-2-4-8-13/h2-10,14H,11-12H2,1H3,(H,21,26)(H,22,23,24)/t14-/m0/s1. InChi Key: LYPAFUINURXJSG-AWEZNQCLSA-N.
Keywords: | 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxo-1,5-benzoxazepin-3-yl]-1H-1,2,4-triazole-5-carboxamide |
Supplier: | Cayman Chemical |
Supplier-Nr: | 29230 |
Properties
Application: | RIPK1 inhibitor |
MW: | 377.4 D |
Formula: | C20H19N5O3 |
Purity: | >98% |
Format: | Solid |
Database Information
CAS : | 1622848-92-3| Matching products |
KEGG ID : | K02861 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H302, H315, H319, H335 |
P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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