GSK180736A

GSK180736A is an inhibitor of Rho-associated kinase 1 (ROCK1, IC50 = 14 nM) and G protein-coupled receptor kinase 2 (GRK2, IC50 = 0.77 µM). It is selective for GRK2 over GRK1, GRK5, and PKA (IC50 = >100 µM for all) and selective for ROCK1 over RSK1 and p20S6K (IC50s = 3,100 and 2,850 nM, respectively). GSK180736A increases maximum contractility in isolated mouse cardiomyocytes when used at a concentration of 1 µM.Formal Name: 4-(4-fluorophenyl)-1,2,3,4-tetrahydro-N-1H-indazol-5-yl-6-methyl-2-oxo-5-pyrimidinecarboxamide. CAS Number: 817194-38-0. Molecular Formula: C19H16FN5O2. Formula Weight: 365.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 70 mg/mL, Ethanol: 3 mg/mL. lambdamax: 286 nm. SMILES: FC1=CC=C(C2NC(NC(C)=C2C(NC3=CC=C(NN=C4)C4=C3)=O)=O)C=C1. InChi Code: InChI=1S/C19H16FN5O2/c1-10-16(17(24-19(27)22-10)11-2-4-13(20)5-3-11)18(26)23-14-6-7-15-12(8-14)9-21-25-15/h2-9,17H,1H3,(H,21,25)(H,23,26)(H2,22,24,27). InChi Key: HEAIGWIZTYAQTC-UHFFFAOYSA-N.