GSK-J2 (sodium salt)

The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. GSK-J2 is a pyridine regio-isomer of GSK-J1 which poorly inhibits JMJD3 (IC50 > 100 µM), making it an appropriate negative control for in vitro studies involving GSK-J1. For in vivo research, cell-permeable prodrug forms of GSK-J1 and GSK-J2 are available as GSK-J4 (Cay-12073) and GSK-J5 (Cay-12074), respectively. See the Structural Genomics Consortium (SGC) website for more information.Formal Name: 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-3-yl)pyrimidin-4-yl)amino)propanoic acid, monosodium salt. CAS Number: 2108665-15-0. Molecular Formula: C22H23N5O2 . Na. Formula Weight: 412.4. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 242 nm. SMILES: OC(CCNC1=CC(N2CCC(C=CC=C3)=C3CC2)=NC(C4=CC=CN=C4)=N1)=O.[Na]. InChi Code: InChI=1S/C22H23N5O2.Na/c28-21(29)7-11-24-19-14-20(26-22(25-19)18-6-3-10-23-15-18)27-12-8-16-4-1-2-5-17(16)9-13-27,/h1-6,10,14-15H,7-9,11-13H2,(H,28,29)(H,24,25,26),. InChi Key: LFPRQFGWKMRKLV-UHFFFAOYSA-N.