GSK-F1

GSK-F1 is a PI4KIIIalpha inhibitor (IC50 = 5.01 nM). It is selective for PI4KIIIalpha over PI4Kbeta, PI3Kalpha, PI3Kbeta, PI3Kdelta, and PI4Kgamma (IC50s = 1,000, 2,512, 7,943, 2,512, and 2,512 nM, respectively). GSK-F1 inhibits the replication of hepatitis C virus (HCV) genotypes 1a, 1b, and 2a in a cell-based replicon assay (IC50s = 12.6, 2.51, and 12.6 nM, respectively).Formal Name: 5-[2-amino-3,4-dihydro-4-oxo-3-[2-(trifluoromethyl)phenyl]-6-quinazolinyl]-N-(2,4-difluorophenyl)-2-methoxy-3-pyridinesulfonamide. CAS Number: 1402345-92-9. Molecular Formula: C27H18F5N5O4S. Formula Weight: 603.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: :, DMSO: Soluble: >10 mg/ml, Ethanol: Slightly soluble: 0.1-1 mg/ml. SMILES: O=C1C2=C(N=C(N1C3=C(C=CC=C3)C(F)(F)F)N)C=CC(C4=CC(S(=O)(NC5=CC=C(C=C5F)F)=O)=C(OC)N=C4)=C2. InChi Code: InChI=1S/C27H18F5N5O4S/c1-41-24-23(42(39,40)36-21-9-7-16(28)12-19(21)29)11-15(13-34-24)14-6-8-20-17(10-14)25(38)37(26(33)35-20)22-5-3-2-4-18(22)27(30,31)32/h2-13,36H,1H3,(H2,33,35). InChi Key: MSRFVAYVUUHQCN-UHFFFAOYSA-N.