GS-704277

GS-704277 is an intermediate alanine metabolite of the antiviral prodrug remdesivir (Cay-30354). It is formed from remdesivir via intracellular hydrolysis. GS-704277 is further metabolized to the nucleoside monophosphate form and then to the nucleoside analog GS-441524 (Cay-30469) or active nucleoside triphosphate GS-443902.Formal Name: N-phosphono-L-alanine, P->6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile. CAS Number: 1911579-04-8. Molecular Formula: C15H19N6O8P. Formula Weight: 442.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 246 nm. SMILES: O=P(N[C@@H](C)C(O)=O)(O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@@](C2=CC=C3N2N=CN=C3N)(C#N)O1. InChi Code: InChI=1S/C15H19N6O8P/c1-7(14(24)25)20-30(26,27)28-4-9-11(22)12(23)15(5-16,29-9)10-3-2-8-13(17)18-6-19-21(8)10/h2-3,6-7,9,11-12,22-23H,4H2,1H3,(H,24,25)(H2,17,18,19)(H2,20,26,27)/t7-,9+,11+,12+,15-/m0/s1. InChi Key: IYHPTSNEWCZBDF-NIFWRESRSA-N.