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GPX4 inhibitor 26a is an inhibitor of glutathione peroxidase 4 (GPX4). It inhibits GPX4 activity by 71.7% at 1 µM. GPX4 inhibitor 26a is cytotoxic to 4T1 and MCF-7 breast cancer cells and HT-1080 fibrosarcoma cells (IC50s = 0.78, 6.9, and 0.15 µM, respectively). It decreases intracellular glutathione (GSH) levels and induces lipid peroxidation and ferroptosis in 4T1 cells when used at a concentration of 5 µM. GPX4 inhibitor 26a (15 and 30 mg/kg) reduces tumor growth in a 4T1 mouse xenograft model.Formal Name: alpha-[(2-chloroacetyl)[4-(5-oxazolyl)phenyl]amino]-N-(2-phenylethyl)-benzo[b]thiophene-3-acetamide. CAS Number: 2761004-85-5. Synonyms: Glutathione Peroxidase 4 Inhibitor 26a, GPX4-IN-3, PHGPx Inhibitor 26a, Phospholipid Hydroperoxide Glutathione Peroxidase Inhibitor 26a. Molecular Formula: C29H24ClN3O3S. Formula Weight: 530.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: soluble. lambdamax: 269 nm. SMILES: ClCC(N(C(C1=CSC2=CC=CC=C21)C(NCCC3=CC=CC=C3)=O)C4=CC=C(C5=CN=CO5)C=C4)=O. InChi Code: InChI=1S/C29H24ClN3O3S/c30-16-27(34)33(22-12-10-21(11-13-22)25-17-31-19-36-25)28(24-18-37-26-9-5-4-8-23(24)26)29(35)32-15-14-20-6-2-1-3-7-20/h1-13,17-19,28H,14-16H2,(H,32,35). InChi Key: ZLCPSXKEQBUXRJ-UHFFFAOYSA-N.
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