GPX4 Inhibitor 17

GPX4 inhibitor 17 is a ferrocene-containing inhibitor of glutathione peroxidase 4 (GPX4) and an inducer of ferroptosis. It inhibits GPX4 activity by 49.16% when used at a concentration of 1 µM. GPX4 inhibitor 17 (0.5 µM) increases the production of reactive oxygen species (ROS) and levels of malondialdehyde (MDA) in OS-RC-2 clear cell renal cell carcinoma cells. It induces ferroptosis in HT-1080 cells (IC50s = 0.007 and 1.486 µM, in the absence and presence of ferrostatin-1, respectively). GPX4 inhibitor 17 (20 mg/kg) reduces tumor volume and intratumoral GPX4 levels in an OS-RC-2 mouse xenograft model.Synonyms: Glutathione Peroxidase 4-IN-17, Glutathione Peroxidase 4 Inhibitor 17, GPX4-IN-17. Molecular Formula: C30H27ClFeN2O3. Formula Weight: 554.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml, Ethanol: Sparingly soluble: 1-10 mg/ml. SMILES: [][Fe][].O=C(C#C)N(C1=CC=C(OC)C(Cl)=C1)C(c2cccc2)C(NCCC3=CC=CC=C3)=O.c4cccc4.