Gomisin D

Gomisin D is a lignan that has been found in S. chinensis and has diverse biological activities, including enzyme inhibitory and antioxidant properties. It inhibits acetylcholinesterase (AChE) with an IC50 value of 7.84 µM. Gomisin D scavenges ABTS (Cay-27317) and 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals (IC50s = 24.5 and 203 µM, respectively). It inhibits the UDP-glucuronosyltransferase (UGT) isoforms UGT1A1 and UGT1A3 by 89.9 and 83.1%, respectively, when used at a concentration of 100 µM. It is selective for UGT1A1 and UGT1A3 over other UGT isoforms at 100 µM.Formal Name: (5S,6S,7S,13aR,16R,17R)-5,6,7,8-tetrahydro-6,17-dihydroxy-1,2,3-trimethoxy-6,7,16,17-tetramethyl-5,13-(epoxybutanoxy)benzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-18-one. CAS Number: 60546-10-3. Molecular Formula: C28H34O10. Formula Weight: 530.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mM. lambdamax: 217 nm. SMILES: COC(C(OC)=C1OC)=CC2=C1C(C(OC[C@H]3C)=C(OCO4)C4=C5)=C5C[C@H](C)[C@](C)(O)[C@@]2([H])OC([C@]3(C)O)=O. InChi Code: InChI=1S/C28H34O10/c1-13-8-15-9-18-22(37-12-36-18)24-19(15)20-16(10-17(32-5)21(33-6)23(20)34-7)25(27(13,3)30)38-26(29)28(4,31)14(2)11-35-24/h9-10,13-14,25,30-31H,8,11-12H2,1-7H3/t13-,14+,25-,27-,28+/m0/s1. InChi Key: VLLFEMVDMFTBHG-KMIFWYFFSA-N. Origin: Plant/Schisandra chinensis.