GNF-2

GNF-2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
LKT-G5320.1 1 mg -

3 - 8 business days*

149.00€
LKT-G5320.5 5 mg -

3 - 8 business days*

268.00€
LKT-G5320.25 25 mg -

3 - 8 business days*

793.00€
 
GNF-2 is an inhibitor of Abl kinase that exhibits anticancer chemotherapeutic, anti-resorptive,... more
Product information "GNF-2"
GNF-2 is an inhibitor of Abl kinase that exhibits anticancer chemotherapeutic, anti-resorptive, and anti-osteoporotic activities. GNF-2 shows potential benefit in the treatment of Philadelphia chromosome-positive acute myelogenous leukemia (ALL). In vitro, GNF-2 inhibits differentiation of osteoclasts, activity of NF-kappaB, and induction of c-Fos and NFATc1, resulting in caspase-mediated apoptosis. GNF-2 also inhibits resorption of mature osteoclasts and prevents phagocytosis in bone marrow-derived macrophages. In vivo, this compound decreases osteoclast numbers and prevents bone loss.
Supplier: LKT Laboratories
Supplier-Nr: G5320

Properties

Application: Bcr-abl inhibitor
MW: 374.32 D
Formula: C18H13F3N4O2
Purity: >98%
Format: Solid

Database Information

CAS : 778270-11-4| Matching products
KEGG ID : K06619 | Matching products

Handling & Safety

Storage: +20°C
Shipping: +20°C (International: °C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P332+313, P337+313, P362+364, P403, P233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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