GNE-495

GNE-495 is an orally bioavailable, potent, and selective MAP4K4 inhibitor (IC50 = 3.7 nM). In cell sprouting assays, it increases the number of protrusions. In a mouse model of oxygen-induced retinopathy, GNE-495 normalizes the percentage of pathological vessels and hemorrhagic areas.Formal Name: 8-amino-N-[1-(cyclopropylcarbonyl)-3-azetidinyl]-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide. CAS Number: 1449277-10-4. Molecular Formula: C22H20FN5O2. Formula Weight: 405.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, DMSO:PBS (pH 7.2) (1:7): 0.125 mg/ml, Ethanol: slightly soluble. lambdamax: 277, 343 nm. SMILES: FC1=CC=CC(C2=NC3=C(N)N=CC(C(NC4CN(C(C5CC5)=O)C4)=O)=C3C=C2)=C1. InChi Code: InChI=1S/C22H20FN5O2/c23-14-3-1-2-13(8-14)18-7-6-16-17(9-25-20(24)19(16)27-18)21(29)26-15-10-28(11-15)22(30)12-4-5-12/h1-3,6-9,12,15H,4-5,10-11H2,(H2,24,25)(H,26,29). InChi Key: FYXCIBJXJYBWPX-UHFFFAOYSA-N.