GN44028

Description: GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1alpha transcriptional activity. However, It can not be suppressing HIF-1alpha mRNA expression, HIF-1alpha protein accumulation, or HIF-1alpha/HIF-1beta heterodimerization. Target: HIF. Smiles: C1c2ccccc2-c2[nH]nc(Nc3ccc4OCCOc4c3)c12. References: Minegishi H, et al. Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors. ACS Med Chem Lett. 2013 Jan 27,4(2):297-301.