Glycopyrrolate

Glycopyrrolate is an antagonist of muscarinic acetylcholine receptors (mAChRs, Kis = 0.42, 1.77, 0.52, 0.78, and 1.29 nM for the M1-M5 receptors, respectively). It induces relaxation of precontracted isolated human bronchi when used at concentrations of 0.01, 0.1, or 1 µM. Glycopyrrolate reduces post-prandial gastric antral motility in dogs when administered at a dose of 0.01 mg/kg. It inhibits salivation in a rat model of sialorrhea induced by pilocarpine with an ED50 value of 0.74 µg/kg. Formulations containing glycopyrrolate have been used in the treatment of sialorrhea, peptic ulcers, and chronic obstructive pulmonary disease (COPD).Formal Name: 3-[(2-cyclopentyl-2-hydroxy-2-phenylacetyl)oxy]-1,1-dimethyl-pyrrolidinium, monobromide. CAS Number: 596-51-0. Synonyms: AHR 504, NSC 250836, NSC 251251, NSC 251252. Molecular Formula: C19H28NO3 . Br. Formula Weight: 398.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(OC1CC[N+](C)(C)C1)C(O)(C2=CC=CC=C2)C3CCCC3.[Br-]. InChi Code: InChI=1S/C19H28NO3.BrH/c1-20(2)13-12-17(14-20)23-18(21)19(22,16-10-6-7-11-16)15-8-4-3-5-9-15,/h3-5,8-9,16-17,22H,6-7,10-14H2,1-2H3,1H/q+1,/p-1. InChi Key: VPNYRYCIDCJBOM-UHFFFAOYSA-M.