Glycerol Phenylbutyrate

Glycerol phenylbutyrate is a pre-prodrug form of the nitrogen-binding prodrug and chemical chaperone sodium 4-phenylbutyrate (Cay-11323). It is converted by pancreatic lipase in the small intestine to sodium 4-phenylbutyrate, which is subsequently converted into the active metabolite phenylacetate via beta-oxidation. Formulations containing glycerol phenylbutyrate have been used in the treatment of urea cycle disorders that cannot be managed by diet or amino acid supplementation alone.Formal Name: benzenebutanoic acid, 1,1',1''-(1,2,3-propanetriyl) ester. CAS Number: 611168-24-2. Synonyms: GPB, HPN-100. Molecular Formula: C33H38O6. Formula Weight: 530.7. Purity: >95%. Formulation: (Request formulation change), A neat oil. Solubility: DMSO: Soluble: >10 mg/ml, Ethanol: Soluble: >10 mg/ml, PBS (pH 7.2): Soluble: >10 mg/ml. SMILES: O=C(CCCC1=CC=CC=C1)OC(COC(CCCC2=CC=CC=C2)=O)COC(CCCC3=CC=CC=C3)=O. InChi Code: InChI=1S/C33H38O6/c34-31(22-10-19-27-13-4-1-5-14-27)37-25-30(39-33(36)24-12-21-29-17-8-3-9-18-29)26-38-32(35)23-11-20-28-15-6-2-7-16-28/h1-9,13-18,30H,10-12,19-26H2. InChi Key: ZSDBFLMJVAGKOU-UHFFFAOYSA-N.