GLS1 Inhibitor

GLS1 inhibitor is an inhibitor of glutaminase 1 (GLS1, IC50 = 0.021 µM). It inhibits the growth of NCI H1703 non-small cell lung cancer (NSCLC) cells in vitro (GI50 = 0.011 µM). GLS1 inhibitor (100 mg/kg) reduces tumor growth, increases tumor levels of glutamine, and decreases tumor levels of glutamate and aspartate in an NCI H1703 mouse xenograft model.Formal Name: alphaS-methoxy-N-[5-[[(3R)-1-(3-pyridazinyl)-3-pyrrolidinyl]amino]-1,3,4-thiadiazol-2-yl]-benzeneacetamide. CAS Number: 1832646-52-2. Molecular Formula: C19H21N7O2S. Formula Weight: 411.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 252, 289 nm. SMILES: CO[C@H](C(NC1=NN=C(N[C@@H]2CCN(C3=CC=CN=N3)C2)S1)=O)C4=CC=CC=C4. InChi Code: InChI=1S/C19H21N7O2S/c1-28-16(13-6-3-2-4-7-13)17(27)22-19-25-24-18(29-19)21-14-9-11-26(12-14)15-8-5-10-20-23-15/h2-8,10,14,16H,9,11-12H2,1H3,(H,21,24)(H,22,25,27)/t14-,16+/m1/s1. InChi Key: KLQLQDLJJUAEGT-ZBFHGGJFSA-N.