GLN-1062

GLN-1062 is a neuroprotective agent and prodrug form of galantamine (Cay-17559, Cay-35247), an alkaloid with acetylcholine esterase (AChE) inhibitory and nicotinic acetylcholine (nAChR) potentiating activities. It also is active against M. tuberculosis and M. aurum (MIC = 31.25 µg/ml for both). GLN-1062 decreases the frequency of spontaneous alternations induced by the alkaloid scopolamine (Cay-40307) in the T maze continuous alternation task in mice (ED50 = 0.34 mg/kg). It inhibits increases in hippocampal and entorhinal cortex amyloid-beta (Abeta) plaque densities in the 5XFAD transgenic mouse model of Alzheimer's disease when administered intranasally at a dose of 6 mg/kg per day. Formulations containing GLN-1062 have been used in the treatment of Alzheimer's disease.Formal Name: (4aS,6R,8aS)-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6-benzoate. CAS Number: 224169-27-1. Synonyms: Benzgalantamine. Molecular Formula: C24H25NO4. Formula Weight: 391.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml, Ethanol: Slightly soluble: 0.1-1 mg/ml. SMILES: COC1=C2C3=C(C=C1)CN(C)CC[C@@]34[C@@](C[C@H](C=C4)OC(C5=CC=CC=C5)=O)([H])O2. InChi Code: InChI=1S/C24H25NO4/c1-25-13-12-24-11-10-18(28-23(26)16-6-4-3-5-7-16)14-20(24)29-22-19(27-2)9-8-17(15-25)21(22)24/h3-11,18,20H,12-15H2,1-2H3/t18-,20-,24-/m0/s1. InChi Key: JKVNJTYHRABHIY-WXVUKLJWSA-N. Origin: Synthetic.