Gitogenin

Description: 1. Gitogenin, tigogenin, and solasodine are novel selective inhibitors of UGT1A4, and do not inhibit the activities of major human CYP isoforms. 2. Gitogenin and (25S)-5alpha-furastan-3beta, 22, 26-triol are the inhibitors of enzyme alpha-glucosidase with IC50 values of 37.2±0.18 and 33.5±0.22 uM, respectively.3. Gitogenin shows moderate stimulation of release activity on growth hormone from rat pituitary cells. Target: UGT. Smiles: [H][C@]12C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@@H](O)[C@H](O)C[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@]1(CC[C@@H](C)CO1)O2. References: Shim S , Lee E , Kim J , et al. Rat Growth-Hormone Release Stimulators from Fenugreek Seeds[J]. Chemistry & Biodiversity, 2008, 5(9):1753-1761.