Gemifloxacin (mesylate)

Gemifloxacin is a fluoroquinolone antibiotic that is effective against C. pneumoniae and M. tuberculosis (MIC50s = 0.25 and 8 µg/ml, respectively). Quinolones, including gemifloxacin, inhibit bacterial DNA gyrase and other topoisomerases. Formulations containing gemifloxacin are useful against respiratory tract infections, particularly community-acquired pneumonia and tuberculosis.Formal Name: 7-[(4Z)-3-(aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, monomethanesulfonate. CAS Number: 210353-53-0. Synonyms: LB 20304a, SB 265805S. Molecular Formula: C18H20FN5O4 . CH3SO3H. Formula Weight: 485.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 15 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 269, 341 nm. SMILES: OC(C1=CN(C2CC2)C3=C(C=C(F)C(N(C/4)CC(CN)C4=N\OC)=N3)C1=O)=O.OS(=O)(C)=O. InChi Code: InChI=1S/C18H20FN5O4.CH4O3S/c1-28-22-14-8-23(6-9(14)5-20)17-13(19)4-11-15(25)12(18(26)27)7-24(10-2-3-10)16(11)21-17,1-5(2,3)4/h4,7,9-10H,2-3,5-6,8,20H2,1H3,(H,26,27),1H3,(H,2,3,4)/b22-14+,. InChi Key: JIYMVSQRGZEYAX-CWUUNJJBSA-N.