Gefitinib
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that... more
Product information "Gefitinib"
Description: Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations. Gefitinib has antitumor activity and is used for the treatment of EGFR-mutated non-small-cell lung cancers. Gefitinib administration RESULTS in the development of the EGFR C797S resistance mutation. Target: Tyrosine Kinases, EGFR, Autophagy. Smiles: N(C=1C2=C(C=C(OC)C(OCCCN3CCOCC3)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4. References: Noro R, et al. Gefitinib (IRESSA) sensitive lung cancer cell lines show phosphorylation of Akt without ligand stimulation. BMC Cancer. 2006 Dec 6,6:277.
| Keywords: | ZD1839 |
| Supplier: | TargetMol |
| Supplier-Nr: | T1181 |
Properties
| Application: | Targets epidermal growth factor receptor [EC:2.7.10.1] (EGFR, ERBB1) |
| MW: | 446.9 D |
| Formula: | C22H24ClFN4O3 |
Database Information
| CAS : | 184475-35-2| Matching products |
| KEGG ID : | K04361 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H318, H351, H361, H373, H411 |
| P Phrases: | P201, P202, P260, P264, P270, P273, P280, P314, P321, P330, P391, P301+P310, P302+P352, P305+P351+P338, P308+P313, P332+P313, P362+P364, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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