GC7 (sulfate)

GC7 is an inhibitor of deoxyhypusine synthase (Ki = 9.7 nM), an enzyme that participates in the biosynthesis of the amino acid hypusine, which is formed post-translationally on eukaryotic initiation factor 5A (eIF5A). It inhibits the production of hypusine in CHO cells when used at a concentration of 1 µM. GC7 (20 µM) inhibits activation of eIF5A2 and enhances the cytotoxicity of doxorubicin in Huh7 and HepG2 cells. It reduces tumor growth in a Melan-a Tm5 murine melanoma model when administered at a dose of 0.9 mg/kg.Formal Name: (7-aminoheptyl)-guanidine, monosulfate. CAS Number: 150417-90-6. Synonyms: N1-Guanyl-1,7-diaminoheptane. Molecular Formula: C8H20N4 . H2SO4. Formula Weight: 270.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: 10 mM AcOH: soluble. SMILES: O=S(O)(O)=O.N=C(NCCCCCCCN)N. InChi Code: InChI=1S/C8H20N4.H2O4S/c9-6-4-2-1-3-5-7-12-8(10)11,1-5(2,3)4/h1-7,9H2,(H4,10,11,12),(H2,1,2,3,4). InChi Key: MDDOWYFCKAAANU-UHFFFAOYSA-N.