Gallocyanine

Gallocyanine is a small molecule blue dye used to stain nuclei. It is known to inhibit Dickkopf-1 (Dkk1), an antagonist of the Wnt pathway. Gallocyanine can disrupt the interaction of Dkk1 with its receptor LRP5/6 (IC50 = 3 µM), thereby activating Wnt/beta-catenin signaling. Modulation of the Dkk1-LRP5/6 interaction via gallocyanine has been shown to inhibit prostaglandin J2-induced tau phosphorylation at serine396 in primary cortical neurons in vitro.Formal Name: 1-carboxy-7-(dimethylamino)-3,4-dihydroxy-phenoxazin-5-ium, monochloride. CAS Number: 1562-85-2. Synonyms: IIIC3, Alizarine Navy Blue, Anthracene Blue SWGG, Brilliant Chrome Blue P, C.I. 51030, Fast Violet, Mordant Blue 10. Molecular Formula: C15H13N2O5 . Cl. Formula Weight: 336.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. lambdamax: 314, 399, 600, 607 nm. SMILES: OC(C1=CC(O)=C(O)C2=[O+]C3=CC(N(C)C)=CC=C3N=C21)=O.[Cl-]. InChi Code: InChI=1S/C15H12N2O5.ClH/c1-17(2)7-3-4-9-11(5-7)22-14-12(16-9)8(15(20)21)6-10(18)13(14)19,/h3-6H,1-2H3,(H2-,16,18,19,20,21),1H. InChi Key: ADAUKUOAOMLVSN-UHFFFAOYSA-N.