(-)-Gallocatechin Gallate

(-)-Gallocatechin gallate ((-)-GCG) is a catechin polyphenol that has been found in oolong tea stems and green tea extracts with diverse biological activities. It inhibits histamine release from anti-egg albumin (EA) IgE antibody-sensitized rat peritoneal mast cells when used at concentrations ranging from 0.1 to 1 mg/ml. (-)-GCG reduces proliferation of MDA-MB-231 breast cancer cells (IC50 = 22 µg/ml) and human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner. It also inhibits human placental aromatase activity (IC50 = 15 µM). (-)-GCG is lytic against T. cruzi amastigotes, with a 50% bactericidal concentration (MBC50) value of 0.12 pM. It also decreases RAW 264.7 osteoclastogenesis when used at a concentration of 20 µM.Formal Name: 3,4,5-trihydroxy-benzoic acid, (2S,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester. CAS Number: 4233-96-9. Synonyms: (-)-GCG, NVP-XAA225. Molecular Formula: C22H18O11. Formula Weight: 458.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 0.3 mg/ml. lambdamax: 211, 275 nm. SMILES: OC1=CC([C@H]2[C@H](OC(C3=CC(O)=C(O)C(O)=C3)=O)CC4=C(O)C=C(O)C=C4O2)=CC(O)=C1O. InChi Code: InChI=1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21+/m1/s1. InChi Key: WMBWREPUVVBILR-NQIIRXRSSA-N.