FX11

FX11 is an inhibitor of lactate dehydrogenase-A (LDH-A, Ki = 8 µM). It is selective for LDH-A over GAPDH (Ki = >300 µM). FX11 increases oxygen consumption and the production of reactive oxygen species (ROS), as well as induces cell death in P493-6 lymphoblastoid cells. In vivo, FX11 (42 µg/animal, i.p.) reduces tumor volume in a P493-6 mouse xenograft model. It also reduces tumor weight in a BxPC-3 mouse xenograft model when administered at a dose of 2 mg/kg.Formal Name: 2,3-dihydroxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic acid. CAS Number: 213971-34-7. Molecular Formula: C22H22O4. Formula Weight: 350.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 233 nm. SMILES: CCCC(C(C=C1C)=C(C=C1CC2=CC=CC=C2)C(C(O)=O)=C3O)=C3O. InChi Code: InChI=1S/C22H22O4/c1-3-7-16-17-10-13(2)15(11-14-8-5-4-6-9-14)12-18(17)19(22(25)26)21(24)20(16)23/h4-6,8-10,12,23-24H,3,7,11H2,1-2H3,(H,25,26). InChi Key: LVPYVYFMCKYFCZ-UHFFFAOYSA-N.