Fuziline

Fuziline is a diterpene alkaloid that has been found in A. lateralis and has cardioprotective activity. It reduces sodium pentobarbital-induced cell death in primary neonatal rat cardiomyocytes when used at concentrations ranging from 0.1 to 10 µM. Fuziline (0.5 µM) reduces the production of reactive oxygen species (ROS) and apoptosis induced by isoproterenol (Cay-15592) in H9c2 rat cardiomyocytes. In vivo, fuziline (3 and 10 mg/kg) reduces isoproterenol-induced myocardial necrosis and fibrosis in rats.Formal Name: (1alpha,6alpha,14alpha,15alpha,16beta)-20-ethyl-6,16-dimethoxy-4-(methoxymethyl)-aconitane-1,8,14,15-tetrol. CAS Number: 80665-72-1. Synonyms: Senbusine C. Molecular Formula: C24H39NO7. Formula Weight: 453.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: soluble, DMSO: soluble. SMILES: O[C@@H]1C2(C3N4CC)[C@@]([C@@H](OC)C3[C@@](O)([C@@H](O)[C@H](OC)[C@H]([C@]5([H])O)C6)[C@@H]5[C@]26[H])([H])[C@](COC)(C4)CC1. InChi Code: InChI=1S/C24H39NO7/c1-5-25-9-22(10-30-2)7-6-13(26)23-12-8-11-16(27)14(12)24(29,21(28)17(11)31-3)15(20(23)25)18(32-4)19(22)23/h11-21,26-29H,5-10H2,1-4H3/t11-,12+,13-,14+,15?,16-,17+,18-,19+,20?,21-,22-,23?,24+/m0/s1. InChi Key: FPECZWKKKKZPPP-WFAXMRCRSA-N. Origin: Plant/Radix Aconiti Carmichaeli.