Fursultiamine

Fursultiamine is a synthetic derivative of vitamin B1 (thiamine, Cay-25332). It reduces LPS-induced increases in IL-6, IL-8, and chemokine (C-C motif) ligand 2 (CCL2) protein levels and decreases in mitochondrial respiration in ARPE-19 retinal pigment epithelial cells when used at concentrations of 100 and 20 µM, respectively. Fursultiamine (50 mg/kg) also reduces the area and severity of laser-induced lesions in a mouse model of choroidal neovascularization (CNV). It increases thiamine levels in various rat tissues, including skeletal muscle and the heart, and prevents physical-fatigue loading decreases in skeletal muscle ATP levels induced by forced swimming with a weight load in rats when administered at a dose of 50 mg/kg. Fursultiamine (100 mg/kg) enhances the protective effects of glucosamine and chondroitin sulfate on cartilage lesion formation in a rabbit model of osteoarthritis.Formal Name: N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-buten-1-yl]-formamide. CAS Number: 804-30-8. Synonyms: Fursultiamin, Thiamine Tetrahydrofurfuryl Disulfide, TTFD. Molecular Formula: C17H26N4O3S2. Formula Weight: 398.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, DMSO:PBS (pH 7.2) (1:9): 0.10 mg/ml, Ethanol: 1 mg/ml. lambdamax: 236 nm. SMILES: O=CN(CC1=CN=C(C)N=C1N)C(C)=C(CCO)SSCC2CCCO2. InChi Code: InChI=1S/C17H26N4O3S2/c1-12(16(5-6-22)26-25-10-15-4-3-7-24-15)21(11-23)9-14-8-19-13(2)20-17(14)18/h8,11,15,22H,3-7,9-10H2,1-2H3,(H2,18,19,20). InChi Key: JTLXCMOFVBXEKD-UHFFFAOYSA-N.