Furosemide sodium

Description: Furosemide sodium (Frusemide Sodium) is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity for alpha6-containing receptors than alpha1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema. Target: Na-K-Cl cotransporter. Smiles: O=C([O-])C1=CC(S(=O)(N)=O)=C(Cl)C=C1NCC2=CC=CO2.[Na+]. References: C M Gillen, et al. Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family. J Biol Chem. 1996 Jul 5,271(27):16237-44.