Fulvestrant 9-sulfone

Fulvestrant 9-sulfone is an estrogen receptor antagonist and a derivative of the selective estrogen receptor degrader (SERD) fulvestrant (Cay-10011269). It binds to estrogen receptor alpha (ERalpha) and ERbeta and inhibits estrogen-induced gene expression in a reporter assay in Ishikawa endometrial cells expressing an estrogen response element (ERE) reporter when used at concentrations ranging from 0.1 to 100 µM.Formal Name: 7alpha-[9-[(4,4,5,5,5-pentafluoropentyl)sulfonyl]nonyl]-estra-1,3,5(10)-triene-3,17beta-diol. CAS Number: 98008-06-1. Molecular Formula: C32H47F5O4S. Formula Weight: 622.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Methanol: slightly soluble. SMILES: OC1=CC=C2C(C[C@@H](CCCCCCCCCS(CCCC(F)(F)C(F)(F)F)(=O)=O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4O)=C1. InChi Code: InChI=1S/C32H47F5O4S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-42(40,41)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+/m1/s1. InChi Key: NQYWBGDKCPOMGL-LSVBPWPTSA-N.