FTase Inhibitor II (trifluoroacetate salt)

Farnesylation involves the utilization of farnesyl pyrophosphate (FPP), an intermediate in the mevalonate pathway, by farnesyltransferase (FTase) to add a lipid, farnesyl, to certain proteins. This post-translational modification is crucial in allowing target proteins, including Ras, to associate with, and function at, membranes. FTase Inhibitor II is a cell-permeable analog of FPP that potently inhibits FTase (IC50 = 50-75 nM), preventing farnesylation of Ras. It does not inhibit geranylgeranyl transferase at similar concentrations (IC50 > 100 µM). FTase Inhibitor II displays no toxicity to untransformed cells but blocks Ras-mediated transformation of NIH 3T3 cells.Formal Name: N-[4-[[(2R)-2-amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine, trifluoroacetate salt. Synonyms: Farnesyltransferase Inhibitor II, FTI-II. Molecular Formula: C15H21N3O4S2 . XCF3COOH. Formula Weight: 371.5. Purity: >80%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: 25 mg/ml. lambdamax: 211, 268 nm. SMILES: O=C(N[C@H](C(O)=O)CCSC)C1=CC=C(NC([C@@H](N)CS)=O)C=C1.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C15H21N3O4S2.C2HF3O2/c1-24-7-6-12(15(21)22)18-13(19)9-2-4-10(5-3-9)17-14(20)11(16)8-23,3-2(4,5)1(6)7/h2-5,11-12,23H,6-8,16H2,1H3,(H,17,20)(H,18,19)(H,21,22),(H,6,7)/t11-,12-,/m0./s1. InChi Key: JZRHODCELOILNW-FXMYHANSSA-N.