FR900359

Description: FR900359, a non-ribosomal cyclic peptide derived from the soil bacterium Chromobacterium oxysporum, is a macrocyclic Gq protein inhibitor that inhibits melanoma cell proliferation and can be used in studies of asthma, inflammation, and cancer. Target: Apoptosis, ERK. Smiles: [C@@H](OC([C@@H](NC(CC)=O)[C@@H](C(C)C)O)=O)(C(C)C)[C@]1(C(=O)N(C)[C@@]([C@H](OC)C)(C(=O)O[C@H](C(C)C)[C@H](NC(C)=O)C(=O)O[C@H](CC2=CC=CC=C2)C(=O)N(C)C(=C)C(=O)N[C@@H](C)C(=O)N(C)[C@@H](C)C(=O)N1)[H])[H]. References: Reher R, Schamari I, Kehraus S, Annala S, Kuschak M, Schäberle T, Crüsemann M, Carlier A, Eberl L, Müller CE, Kostenis E, König GM. The endophyte Candidatus Burkholderia crenata of the TCM plant Ardisia crenata produces the selective Gq-inhibitor FR900359. Planta Med. 2016 Dec,81(S 01):S1-S381. PubMed PMID: 27975935.