FOY-251

FOY-251 is an active metabolite of the antiviral protease inhibitor camostat (Cay-16018). It inhibits transmembrane serine protease 2 (TMPRSS2, IC50 = 33.3 nM). FOY-251 inhibits entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pseudotyped particles in Calu-3 cells (EC50 = 178 nM) and reduces viral titers in SARS-CoV-2-infected Calu-3 cells when used at concentrations ranging from 1 to 10 µM.Formal Name: 4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]-benzeneacetic acid, monomethanesulfonate. CAS Number: 71079-09-9. Molecular Formula: C16H15N3O4 . CH3SO3H. Formula Weight: 409.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 2 mg/ml, DMSO: 3 mg/ml. lambdamax: 266 nm. SMILES: O=C(C1=CC=C(NC(N)=N)C=C1)OC2=CC=C(CC(O)=O)C=C2.O=S(O)(C)=O. InChi Code: InChI=1S/C16H15N3O4.CH4O3S/c17-16(18)19-12-5-3-11(4-6-12)15(22)23-13-7-1-10(2-8-13)9-14(20)21,1-5(2,3)4/h1-8H,9H2,(H,20,21)(H4,17,18,19),1H3,(H,2,3,4). InChi Key: JXMOPIDYHUYOED-UHFFFAOYSA-N.