Fosamprenavir (calcium salt)

Fosamprenavir is a prodrug form of the HIV-1 protease inhibitor amprenavir (Cay-15369). It is converted to amprenavir by alkaline phosphatase in the intestinal epithelium. Formulations containing fosamprenavir have been used in the treatment of HIV infections.Formal Name: N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)-2-(phosphonooxy)propyl]-carbamic acid, (3S)-tetrahydro-3-furanyl ester, monocalcium salt. CAS Number: 226700-81-8. Synonyms: GW 433908G. Molecular Formula: C25H34N3O9PS . Ca. Formula Weight: 623.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2)(1:8): 0.11 mg/ml, Ethanol: 2 mg/ml. lambdamax: 268 nm. SMILES: NC1=CC=C(S(N(C[C@@H](OP([O-])([O-])=O)[C@H](CC2=CC=CC=C2)NC(O[C@H]3CCOC3)=O)CC(C)C)(=O)=O)C=C1.[Ca+2]. InChi Code: InChI=1S/C25H36N3O9PS.Ca/c1-18(2)15-28(39(33,34)22-10-8-20(26)9-11-22)16-24(37-38(30,31)32)23(14-19-6-4-3-5-7-19)27-25(29)36-21-12-13-35-17-21,/h3-11,18,21,23-24H,12-17,26H2,1-2H3,(H,27,29)(H2,30,31,32),/q,+2/p-2/t21-,23-,24+,/m0./s1. InChi Key: PMDQGYMGQKTCSX-HQROKSDRSA-L.