Fludarabine Phosphate

Fludarabine phosphate is a prodrug form of fludarabine (Cay-14128) and 2-fluoro-ara-ATP. It is dephosphorylated in vivo to fludarabine and re-phosphorylated intracellularly to the active form, 2-fluoro-ara-ATP, which inhibits DNA synthesis. Fludarabine phosphate reduces viability of, and induces apoptosis in, N-Myc-overexpressing LASCPC-01 neuroendocrine prostate cancer cells (IC50 = 17.67 µM). It also reduces N-Myc protein levels when used at a concentration of 25 µM for at least 48 hours but does not reduce the levels of N-Myc mRNA. Fludarabine phosphate (120 mg/kg per day) reduces tumor volume in N-Myc-overexpressing 22Rv1-N-Myc and LASCPC-01, but not non-N-Myc-overexpressing 22Rv1, mouse xenograft models. Fludarabine phosphate is also an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp, EC50 = 0.93 µM). Formulations containing fludarabine phosphate have been used in the treatment of B cell chronic lymphocytic leukemia (CLL).Formal Name: 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine. CAS Number: 75607-67-9. Synonyms: 2F-ara-AMP, 2-fluoro-ara-AMP, 2-fluoroadenine Arabinoside-5-phosphate, FAMP, NSC 312887, NSC 328002. Molecular Formula: C10H13FN5O7P. Formula Weight: 365.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 3 mg/ml. lambdamax: 261 nm. SMILES: OP(OC[C@@H]1[C@@H](O)[C@H](O)[C@H](N2C=NC3=C2N=C(F)N=C3N)O1)(O)=O. InChi Code: InChI=1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9-/m1/s1. InChi Key: GIUYCYHIANZCFB-FJFJXFQQSA-N.