Florfenicol-d3

Florfenicol-d3 is intended for use as an internal standard for the quantification of florfenicol (Cay-19458) by GC- or LC-MS. Florfenicol is a broad-spectrum fluorinated antibiotic and a derivative of thiamphenicol (Cay-21357). It is active against human clinical isolates of enteric bacteria, including E. coli, Klebsiella, Enterobacter, Citrobacter, P. mirabilis, and Salmonella (MIC50s = 6.3-12.5 µg/ml). Florfenicol is also active against clinical isolates of various bovine and porcine respiratory tract pathogens, including P. multocida, A. pleuropneumoniae, and B. bronchiseptica (MIC50s = 0.25-4 µg/ml). It inhibits peptidyl transferase activity in 70S ribosomes isolated from E. coli when used at a concentration of 1 mM. Formulations containing florfenicol have been used in the treatment of infectious respiratory disease in cattle.Formal Name: 2,2-dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methyl-d3-sulfonyl)phenyl]ethyl]-acetamide. CAS Number: 2213400-85-0. Molecular Formula: C12H11Cl2D3FNO4S. Formula Weight: 361.2. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMF: slightly soluble, DMSO: slightly soluble, Methanol: slightly soluble. SMILES: O=S(C1=CC=C([C@@H](O)[C@H](NC(C(Cl)Cl)=O)CF)C=C1)(C([2H])([2H])[2H])=O. InChi Code: InChI=1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1/i1D3. InChi Key: AYIRNRDRBQJXIF-BFHKXKNSSA-N.