FIT-039

Description: FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 µM,CDK9/cyclin T1). FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 µM), HSV-2, human adenovirus, and human CMV. FIT-039 is a promising antiviral agent for inhibiting drug-resistant HSVs and other DNA viruses. Target: HSV, Others, DNA/RNA Synthesis, CDK. Smiles: Fc1ccc(N2CCCCC2)c(NC(=S)c2ccncc2)c1. References: Ajiro M , Sakai H , Onogi H , et al. CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia.[J]. 2018.