Finasteride

Finasteride
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14938-50 50 mg -

6 - 10 business days*

50.00€
Cay14938-100 100 mg -

6 - 10 business days*

76.00€
Cay14938-250 250 mg -

6 - 10 business days*

156.00€
 
Finasteride is a 4-azasteroid competitive inhibitor of 5alpha-reductase type II (IC50 = 4.2 nM)... more
Product information "Finasteride"
Finasteride is a 4-azasteroid competitive inhibitor of 5alpha-reductase type II (IC50 = 4.2 nM) and a derivative of testosterone. It is 100-fold selective for 5alpha-reductase type II over type I. Finasteride (10 µM) does not affect the growth of androgen-refractory PC3 prostate cancer cells but increases the protein levels of Nrf2 and heme oxygenase-1 (HO-1). It decreases prostatic diameter and volume, as well as dihydrotestosterone, but not testosterone, serum levels in dogs with spontaneous benign prostatic hypertrophy when administered at doses of 0.1 and 0.5 mg/kg. Finasteride reduces testosterone-induced type I procollagen and TGF-beta1 protein levels in cultured human scalp dermal fibroblasts in a model of androgenic alopecia when applied at a concentration of 0.1 µM. Formulations containing finasteride have been used in the treatment of benign prostatic hyperplasia and androgenic alopecia in men.Formal Name: (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(1,1-dimethylethyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide. CAS Number: 98319-26-7. Synonyms: MK-906. Molecular Formula: C23H36N2O2. Formula Weight: 372.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 16 mg/ml, Ethanol: 25 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. SMILES: O=C(NC(C)(C)C)[C@H]1CC[C@]2([H])[C@]1(C)CC[C@@]3([H])[C@@]2([H])CC[C@]4([H])[C@]3(C)C=CC(N4)=O. InChi Code: InChI=1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1. InChi Key: DBEPLOCGEIEOCV-WSBQPABSSA-N.
Keywords: MK-906, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(1,1-dimethylethyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide
Supplier: Cayman Chemical
Supplier-Nr: 14938

Properties

Application: Type II 5alpha-reductase inhibitor
MW: 372.5 D
Formula: C23H36N2O2
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 98319-26-7| Matching products
KEGG ID : K12344 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H302, H360, H372, H400, H410
P Phrases: P201, P202, P260, P264, P270, P273, P280, P301+310, P308+313, P314, P330, P391, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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