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Product information "FFN-102 (trifluoroacetate salt)"
FFN-102 is a fluorescent false neurotransmitter (FFN) that is a substrate for the dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2). It is a pH-dependent fluorescent probe that labels dopamine cell bodies, axons, and presynaptic terminals. It can also be used to monitor dopamine exocytosis. It has a pKa of 6.2 and displays pH-dependent excitation spectra of 340 and 370 nm at pH 5 and 7.4, respectively, which correspond to vesicular and cytoplasmic pH values. The emission spectrum of FFN-102 is pH-independent at 453 nm, but the intensity of emission is pH-dependent with a higher intensity at a pH of 7.4. FFN-102 inhibits DAT (13.6% at a concentration of 10 µM) and the serotonin (5-HT) receptor subtype 5-HT2c (Ki = ~3 µM) but does not bind to 37 other central nervous system receptors and transporters, including dopamine receptors, up to a concentration of 10 µM.Formal Name: 4-(2-aminoethyl)-6-chloro-7-hydroxy-2H-1-benzopyran-2-one 2,2,2-trifluoroacetate. CAS Number: 1234064-11-9. Molecular Formula: C11H10ClNO3 . CF3COOH. Formula Weight: 353.7. Purity: >98%. Emission: 453 nm. Excitation: 340 nm (pH 5), 370 nm (pH 7.4). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml. lambdamax: 225, 331 nm. SMILES: OC1=C(Cl)C=C(C(CCN)=CC(O2)=O)C2=C1.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C11H10ClNO3.C2HF3O2/c12-8-4-7-6(1-2-13)3-11(15)16-10(7)5-9(8)14,3-2(4,5)1(6)7/h3-5,14H,1-2,13H2,(H,6,7). InChi Key: OGHPXKAKVMJGQH-UHFFFAOYSA-N.
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