Fenticonazole (nitrate)

Fenticonazole is an imidazole with antimicrobial activity. It is active against clinical isolates of Candida species, including C. albicans, C. parapsilosis, C. tropicalis, C. krusei, and C. guilliermondii with MIC values ranging from 0.12 to 32 µg/ml. It is also active against clinical isolates of bacteria, including B. fragilis, associated with bacterial vaginosis (MICs = =0.03-16 µg/ml), as well as bacteria, including S. aureus and S. epidermidis, associated with skin infections with MIC values ranging from 0.03 µg/ml or less to greater than 16 µg/ml. Fenticonazole inhibits fungal growth in a guinea pig model of experimental M. canis dermatomycosis (ED50 = 0.5%, applied topically).Formal Name: 1-[2-(2,4-dichlorophenyl)-2-[[4-(phenylthio)phenyl]methoxy]ethyl]-1H-imidazole, mononitrate. CAS Number: 73151-29-8. Synonyms: REC 15-1476. Molecular Formula: C24H20Cl2N2OS . HNO3. Formula Weight: 518.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: soluble, Methanol: soluble. SMILES: ClC1=CC(Cl)=CC=C1C(CN2C=NC=C2)OCC(C=C3)=CC=C3SC4=CC=CC=C4.O=[N](O)=O. InChi Code: InChI=1S/C24H20Cl2N2OS.HNO3/c25-19-8-11-22(23(26)14-19)24(15-28-13-12-27-17-28)29-16-18-6-9-21(10-7-18)30-20-4-2-1-3-5-20,2-1(3)4/h1-14,17,24H,15-16H2,(H,2,3,4). InChi Key: FJNRUWDGCVDXLU-UHFFFAOYSA-N.