(+)-Fenfluramine (hydrochloride)

(+)-Fenfluramine is an agonist of the serotonin (5-HT) receptor subtypes 5-HT2B and 5-HT2C. It induces serotonin release from superfused midbrain synaptosome preparations isolated from wild-type mice, but not 5-HT2B-/- mice, when used at concentrations of 0.5 or 1 µM. (+)-Fenfluramine (3 or 10 mg/kg) reduces food intake in starved wild-type mice but not in starved 5-HT2B-/- mice. It reduces body weight gain in wild-type mice when infused at a dose of 2.5 mg/kg per day for 35 days. Formulations containing (+)-fenfluramine were previously used in the treatment of obesity.Formal Name: N-ethyl-alpha-methyl-3-(trifluoromethyl)-benzeneethanamine, monohydrochloride. CAS Number: 3239-45-0. Synonyms: Dexfenfluramine. Molecular Formula: C12H16F3N . HCl. Formula Weight: 267.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble, Water: Soluble. SMILES: CCN[C@@H](C)CC1=CC(C(F)(F)F)=CC=C1.Cl. InChi Code: InChI=1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15,/h4-6,8-9,16H,3,7H2,1-2H3,1H/t9-,/m0./s1. InChi Key: ZXKXJHAOUFHNAS-FVGYRXGTSA-N.