Fendiline (hydrochloride)

Fendiline is an alpha2-adrenergic receptor antagonist (Kd = 2.6 µM) and an L-type calcium channel blocker (IC50 = 17 µM) well-known for its coronary vasodilator effects. Fendiline has recently been reported to inhibit K-Ras plasma membrane localization (IC50 = 9.64 µM), which prevents K-Ras signal transduction and blocks the proliferation of K-Ras-transformed tumor cells.Formal Name: gamma-phenyl-N-(1-phenylethyl)-benzenepropanamine, monohydrochloride. CAS Number: 13636-18-5. Molecular Formula: C23H25N . HCl. Formula Weight: 351.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 30 mg/ml, Ethanol: 15 mg/ml, PBS (pH 7.2): 0.1 mg/ml. SMILES: CC(C1=CC=CC=C1)NCCC(C2=CC=CC=C2)C3=CC=CC=C3.Cl. InChi Code: InChI=1S/C23H25N.ClH/c1-19(20-11-5-2-6-12-20)24-18-17-23(21-13-7-3-8-14-21)22-15-9-4-10-16-22,/h2-16,19,23-24H,17-18H2,1H3,1H. InChi Key: NJXWZWXCHBNOOG-UHFFFAOYSA-N.