Fenclofenac

Fenclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 7 and 4 µM for COX-1 and COX-2, respectively). It reduces paw volume in a rat model of adjuvant-induced polyarthritis when administered at doses of 3, 15, and 75 mg/kg and reverses yeast-induced motor impairments, a measure of nociception, in rats (ED50 = 54.3 mg/kg). Fenclofenac (20-180 mg/kg) reduces carrageenan-induced paw edema in rats. Formulations containing fenclofenac have previously been used in the treatment of rheumatoid arthritis.Formal Name: 2-(2,4-dichlorophenoxy)-benzeneacetic acid. CAS Number: 34645-84-6. Synonyms: RX-67408. Molecular Formula: C14H10Cl2O3. Formula Weight: 297.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml, DMSO: Sparingly Soluble: 1-10 mg/ml. SMILES: ClC1=CC(Cl)=CC=C1OC2=C(CC(O)=O)C=CC=C2. InChi Code: InChI=1S/C14H10Cl2O3/c15-10-5-6-13(11(16)8-10)19-12-4-2-1-3-9(12)7-14(17)18/h1-6,8H,7H2,(H,17,18). InChi Key: IDKAXRLETRCXKS-UHFFFAOYSA-N.